Regorafenib-13C-d3 CAS 755037-03-7 (Unlabeled)
| CAS No. | 755037-03-7 (Unlabeled) |
| Molecular Formula | C20[13C]H12D3ClF4N4O3 |
| Molecular Weight | 486.83 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Regorafenib-13C-d3 (CAS 755037-03-7 (Unlabeled)), a certified reference material (molecular formula C20[13C]H12D3ClF4N4O3, MW 486.83 g/mol) for analytical method development and quality control.
The molecular framework of Regorafenib-13C-d3 (C20[13C]H12D3ClF4N4O3) is characterized by deuterium isotope labeling, a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures Regorafenib-13C-d3 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20[13C]H12D3ClF4N4O3 |
| Molecular Weight | 486.83 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Regorafenib Standards
- Regorafenib-13C-D3 (CAS 2126178-55-8)
- Regorafenib D3 (CAS 1255386-16-3)
- Regorafenib Impurity 14 (CAS 835621-12-0)
- Regorafenib Impurity 75 (CAS CATO-C4X-104775)
- Regorafenib (CAS 755037-03-7)
- Regorafenib Impurity 52 (CAS CATO-C4X-104752)
- Regorafenib Impurity 7 (CAS CATO-C4X-10477)
- Regorafenib Impurity 13 (CAS 835621-11-9)
Recommended Standards
- Saflufenacil-N-desmethyl (CAS 854122-75-1)
- Ethyl 10-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl](methyl)amino}-9,11-dioxo-3-oxa-4,10-diazatetracyclo[5.5.1.0^{2,6}.0^{8,12}]tridec-4-ene-5-carboxylate (CAS 321385-52-8)
- (20S)-21-[[Tris(isopropyll)silyl]oxy]-20-methyl-pregn-4-en-3-one (CAS 356063-47-3)
- 4-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-[(1E)-{[(4-nitrophenyl)methoxy]amino}methylidene]piperazine-1-carboxamide (CAS 339029-32-2)
- 2-(Methylthio)-N-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-4-yl)acetamide (CAS 2246709-52-2)
- Ethyl 3-chloro-2-fluoro-5-(trifluoromethyl)benzoate (CAS 773135-53-8)
- (2S,5R)-5-methylpiperidine-2-carboxylic acid (CAS 757920-17-5)
- 4,5-Dichloro-2-(difluoromethoxy)cinnamic acid (CAS 1807333-85-2)
- 4-(1,2,3-Thiadiazol-4-yl)benzonitrile (CAS 82894-99-3)
- Iopamidol impurity 59 (CAS CATO-C4X-145059)
- 3-(Cyclohexylamino)-1,1,1-trifluoropropan-2-ol (CAS 478050-18-9)
- 4-Bromo-N-(1-(2-methoxyethyl)-1,2,3,4-tetrahydroquinolin-7-yl)benzamide (CAS 1172394-45-4)
- 2-(4-Chlorophenyl)-1,3-thiazole-5-carbaldehyde (CAS 721920-84-9)
- Semaglutide impurity 255 (CAS CATO-C4X-2226255)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com